Food systems today contribute to and are confronted by a daunting array of challenges. To address them, policymakers and other decision-makers need to understand links and feedbacks between these various challenges – across space, over time, and across a variety of biophysical and socioeconomic dimensions. In this chapter, we focus on a relatively macro scale using as an example the International Model for Policy Analysis of Agricultural Commodities and Trade (IMPACT). IMPACT is an integrated system of modeling tools that allows exploration of interactions between biophysical and socioeconomic drivers and impacts in food systems at national, regional and global levels, over a period of several decades. Better understanding of these interactions and impacts can help food producers, consumers, businesses, and policymakers make better-informed decisions today to improve the food systems of tomorrow.