Climate change is expected to considerably affect the water resources in the Indus River basin in Pakistan and thus agricultural production in the country. This article reports an analysis of the impacts of various climate scenarios on both water resources and food production out to 2050. While changes in water availability range from –12% to +24%, depending on the scenario, crop yield and production impacts are negative across all scenarios, and net food imports increase. We suggest a combination of accelerated investment in agricultural research and increased water-use efficiency in agriculture to reduce the adverse impacts of climate change on water and food.